Last week, a very interesting review paper came out that looks at the "main form and functions, special needs and risk factors, optimal treatment strategies, pharmacological dosing, and clinical implications". The researchers looked at several previous studies that investigated micronutrients, including vitamins A, B1, B2, B3, B6, folate,C, D, and E, and copper, iron, selenium, zinc, and carnitine.
They conclude that "high‐dose monotherapy of MNs is not recommended. Basal daily needs must be provided, with higher doses in some diseases with identified higher needs, and deficiencies must be treated according to MN guidelines."
We are very happy with this systematic review, as it sheds light on both the role of each micronutiënt alone, as well as making a case for combined use.
"What do we know about micronutrients in critically ill patients? A narrative review." de Man et al., Journal of Parenteral and Enteral Nutrition (2024).
The full article can be freely accessed HERE.